1p6a: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_12 Human adenovirus 12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6A FirstGlance]. <br> | <table><tr><td colspan='2'>[[1p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_12 Human adenovirus 12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6A FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kac|1kac]], [[1p69|1p69]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kac|1kac]], [[1p69|1p69]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6a RCSB], [http://www.ebi.ac.uk/pdbsum/1p6a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6a RCSB], [http://www.ebi.ac.uk/pdbsum/1p6a PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref> [[http://www.uniprot.org/uniprot/SPIKE_ADE12 SPIKE_ADE12]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human adenovirus 12]] | [[Category: Human adenovirus 12]] | ||
[[Category: Bewley, M C | [[Category: Bewley, M C]] | ||
[[Category: Flanagan, J M | [[Category: Flanagan, J M]] | ||
[[Category: Freimuth, P | [[Category: Freimuth, P]] | ||
[[Category: Graziano, V | [[Category: Graziano, V]] | ||
[[Category: Howitt, J | [[Category: Howitt, J]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
[[Category: Viral protein-receptor complex]] | [[Category: Viral protein-receptor complex]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
