4p0w: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4p0w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0W FirstGlance]. <br> | <table><tr><td colspan='2'>[[4p0w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0W FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XH:2-{[(1S,2R,4AS,8AR)-1,2,4A-TRIMETHYL-5-METHYLIDENEDECAHYDRONAPHTHALEN-1-YL]METHYL}CYCLOHEXA-2,5-DIENE-1,4-DIONE'>1XH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XH:2-{[(1S,2R,4AS,8AR)-1,2,4A-TRIMETHYL-5-METHYLIDENEDECAHYDRONAPHTHALEN-1-YL]METHYL}CYCLOHEXA-2,5-DIENE-1,4-DIONE'>1XH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0w RCSB], [http://www.ebi.ac.uk/pdbsum/4p0w PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0w RCSB], [http://www.ebi.ac.uk/pdbsum/4p0w PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Liu, Y L | [[Category: Liu, Y L]] | ||
[[Category: Oldfield, E | [[Category: Oldfield, E]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
[[Category: Fpp]] | [[Category: Fpp]] | ||
