3k2i: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K2I FirstGlance]. <br> | <table><tr><td colspan='2'>[[3k2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K2I FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k2i RCSB], [http://www.ebi.ac.uk/pdbsum/3k2i PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k2i RCSB], [http://www.ebi.ac.uk/pdbsum/3k2i PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACOT4_HUMAN ACOT4_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Palmitoyl-CoA hydrolase]] | [[Category: Palmitoyl-CoA hydrolase]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Berg, S Van Den | [[Category: Berg, S Van Den]] | ||
[[Category: Berglund, H | [[Category: Berglund, H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Collins, R | [[Category: Collins, R]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Flodin, S | [[Category: Flodin, S]] | ||
[[Category: Flores, A | [[Category: Flores, A]] | ||
[[Category: Graslund, S | [[Category: Graslund, S]] | ||
[[Category: Hammarstrom, M | [[Category: Hammarstrom, M]] | ||
[[Category: Johansson, A | [[Category: Johansson, A]] | ||
[[Category: Johansson, I | [[Category: Johansson, I]] | ||
[[Category: Kallas, A | [[Category: Kallas, A]] | ||
[[Category: Karlberg, T | [[Category: Karlberg, T]] | ||
[[Category: Kotenyova, T | [[Category: Kotenyova, T]] | ||
[[Category: Kotzsch, A | [[Category: Kotzsch, A]] | ||
[[Category: Kraulis, P | [[Category: Kraulis, P]] | ||
[[Category: Markova, N | [[Category: Markova, N]] | ||
[[Category: Moche, M | [[Category: Moche, M]] | ||
[[Category: Nielsen, T K | [[Category: Nielsen, T K]] | ||
[[Category: Nordlund, P | [[Category: Nordlund, P]] | ||
[[Category: Nyman, T | [[Category: Nyman, T]] | ||
[[Category: Persson, C | [[Category: Persson, C]] | ||
[[Category: Roos, A K | [[Category: Roos, A K]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schuler, H | [[Category: Schuler, H]] | ||
[[Category: Schutz, P | [[Category: Schutz, P]] | ||
[[Category: Siponen, M I | [[Category: Siponen, M I]] | ||
[[Category: Svensson, L | [[Category: Svensson, L]] | ||
[[Category: Thorsell, A G | [[Category: Thorsell, A G]] | ||
[[Category: Tresaugues, L | [[Category: Tresaugues, L]] | ||
[[Category: Wahlberg, E | [[Category: Wahlberg, E]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Welin, M | [[Category: Welin, M]] | ||
[[Category: Wisniewska, M | [[Category: Wisniewska, M]] | ||
[[Category: Alpha/beta hydrolase fold seven-stranded beta-sandwich]] | [[Category: Alpha/beta hydrolase fold seven-stranded beta-sandwich]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| Line 65: | Line 67: | ||
[[Category: Serine esterase]] | [[Category: Serine esterase]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
