1gd2

CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA

spinqualitylabelsall models 1gd2, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1gd2 is a 10 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Function [AP1_SCHPO] Required for SPK1-confered staurosporine resistance. Can confer resistance alone in high levels. Transcriptional activator that recognizes the 5'-TGACTCA-3' sequence element common in GN4/AP-1 sites. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The basic region leucine zipper (bZIP) proteins form one of the largest families of transcription factors in eukaryotic cells. Despite relatively high homology between the amino acid sequences of the bZIP motifs, these proteins recognize diverse DNA sequences. Here we report the 2.0 A resolution crystal structure of the bZIP motif of one such transcription factor, PAP1, a fission yeast AP-1-like transcription factor that binds DNA containing the novel consensus sequence TTACGTAA. The structure reveals how the Pap1-specific residues of the bZIP basic region recognize the target sequence and shows that the side chain of the invariant Asn in the bZIP motif adopts an alternative conformation in Pap1. This conformation, which is stabilized by a Pap1-specific residue and its associated water molecule, recognizes a different base in the target sequence from that in other bZIP subfamilies. Structural basis for the diversity of DNA recognition by bZIP transcription factors.,Fujii Y, Shimizu T, Toda T, Yanagida M, Hakoshima T Nat Struct Biol. 2000 Oct;7(10):889-93. PMID:11017199 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Tomato aspermy virus protein 2b Suppression of RNA Silencing User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing

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