4h7c: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4h7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7C FirstGlance]. <br> | <table><tr><td colspan='2'>[[4h7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7C FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10H:1-(4-{[(2R)-2-METHYLPIPERIDIN-1-YL]SULFONYL}PHENYL)-1,3-DIHYDRO-2H-PYRROL-2-ONE'>10H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10H:1-(4-{[(2R)-2-METHYLPIPERIDIN-1-YL]SULFONYL}PHENYL)-1,3-DIHYDRO-2H-PYRROL-2-ONE'>10H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7c RCSB], [http://www.ebi.ac.uk/pdbsum/4h7c PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7c RCSB], [http://www.ebi.ac.uk/pdbsum/4h7c PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Denny, W A | [[Category: Denny, W A]] | ||
[[Category: Flanagan, J U | [[Category: Flanagan, J U]] | ||
[[Category: Heinrich, D | [[Category: Heinrich, D]] | ||
[[Category: Jamieson, S M.F | [[Category: Jamieson, S M.F]] | ||
[[Category: Owen, P J | [[Category: Owen, P J]] | ||
[[Category: Raynham, T | [[Category: Raynham, T]] | ||
[[Category: Rigoreau, L J.M | [[Category: Rigoreau, L J.M]] | ||
[[Category: Samlal, S S | [[Category: Samlal, S S]] | ||
[[Category: Schroeder, E | [[Category: Schroeder, E]] | ||
[[Category: Silva, S | [[Category: Silva, S]] | ||
[[Category: Soudy, C | [[Category: Soudy, C]] | ||
[[Category: Trivier, E | [[Category: Trivier, E]] | ||
[[Category: Turnbull, A P | [[Category: Turnbull, A P]] | ||
[[Category: Aldo-keto reductase]] | [[Category: Aldo-keto reductase]] | ||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
[[Category: Tim-barrel]] | [[Category: Tim-barrel]] | ||
