1j74: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1j74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J74 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1j74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J74 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j74 RCSB], [http://www.ebi.ac.uk/pdbsum/1j74 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j74 RCSB], [http://www.ebi.ac.uk/pdbsum/1j74 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/UB2V2_HUMAN UB2V2_HUMAN]] Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.<ref>PMID:9705497</ref> <ref>PMID:10089880</ref> <ref>PMID:14562038</ref> <ref>PMID:20061386</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Edwards, R A | [[Category: Edwards, R A]] | ||
[[Category: Ellison, M J | [[Category: Ellison, M J]] | ||
[[Category: Glover, J N.M | [[Category: Glover, J N.M]] | ||
[[Category: McKenna, S | [[Category: McKenna, S]] | ||
[[Category: Moraes, T F | [[Category: Moraes, T F]] | ||
[[Category: Pastushok, L | [[Category: Pastushok, L]] | ||
[[Category: Xiao, W | [[Category: Xiao, W]] | ||
[[Category: Dna repair]] | [[Category: Dna repair]] | ||
[[Category: Mms2]] | [[Category: Mms2]] | ||
