2coj: Difference between revisions

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[[Image:2coj.gif|left|200px]]<br /><applet load="2coj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2coj.gif|left|200px]]
caption="2coj, resolution 2.40&Aring;" />
 
'''Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin'''<br />
{{Structure
|PDB= 2coj |SIZE=350|CAPTION= <scene name='initialview01'>2coj</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene> and <scene name='pdbligand=GBN:[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID'>GBN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Branched-chain-amino-acid_transaminase Branched-chain-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.42 2.6.1.42]
|GENE=
}}
 
'''Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2COJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=PLP:'>PLP</scene> and <scene name='pdbligand=GBN:'>GBN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Branched-chain-amino-acid_transaminase Branched-chain-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.42 2.6.1.42] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COJ OCA].  
2COJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COJ OCA].  


==Reference==
==Reference==
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin., Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam MM, Hutson SM, J Biol Chem. 2005 Nov 4;280(44):37246-56. Epub 2005 Sep 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16141215 16141215]
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin., Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam MM, Hutson SM, J Biol Chem. 2005 Nov 4;280(44):37246-56. Epub 2005 Sep 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16141215 16141215]
[[Category: Branched-chain-amino-acid transaminase]]
[[Category: Branched-chain-amino-acid transaminase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: plp-dependent enzyme]]
[[Category: plp-dependent enzyme]]


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