3tbv: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:3tbv.jpg|left|200px]]
==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G,V3P,Y4A)==
<StructureSection load='3tbv' size='340' side='right' caption='[[3tbv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tbv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3qul|3qul]], [[3quk|3quk]], [[3tbs|3tbs]], [[3tbt|3tbt]], [[3tbw|3tbw]], [[3tbx|3tbx]], [[3tby|3tby]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbv RCSB], [http://www.ebi.ac.uk/pdbsum/3tbv PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity).  Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity).  Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


{{STRUCTURE_3tbv|  PDB=3tbv  |  SCENE= }}
==See Also==
 
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
===CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G,V3P,Y4A)===
*[[Major histocompatibility complex|Major histocompatibility complex]]
 
__TOC__
 
</StructureSection>
==About this Structure==
[[3tbv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBV OCA].
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Achour, A.]]
[[Category: Achour, A]]
[[Category: Allerbring, E B.]]
[[Category: Allerbring, E B]]
[[Category: Badia-Martinez, D.]]
[[Category: Badia-Martinez, D]]
[[Category: Duru, A D.]]
[[Category: Duru, A D]]
[[Category: Madhurantakam, C.]]
[[Category: Madhurantakam, C]]
[[Category: Mazumdar, P A.]]
[[Category: Mazumdar, P A]]
[[Category: Nygren, P.]]
[[Category: Nygren, P]]
[[Category: Sandalova, T.]]
[[Category: Sandalova, T]]
[[Category: Uchtenhagen, H.]]
[[Category: Uchtenhagen, H]]
[[Category: Agonism]]
[[Category: Agonism]]
[[Category: Altered peptide ligand]]
[[Category: Altered peptide ligand]]
Retrieved from "https://proteopedia.org/3tbv"