2l08: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l08 RCSB], [http://www.ebi.ac.uk/pdbsum/2l08 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l08 RCSB], [http://www.ebi.ac.uk/pdbsum/2l08 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/REN3A_HUMAN REN3A_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.<ref>PMID:11163187</ref> <ref>PMID:16601204</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Acton, T B | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C | [[Category: Ciccosanti, C]] | ||
[[Category: Everett, J K | [[Category: Everett, J K]] | ||
[[Category: Mani, R | [[Category: Mani, R]] | ||
[[Category: Mao, L | [[Category: Mao, L]] | ||
[[Category: Montelione, G T | [[Category: Montelione, G T]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Shastry, R | [[Category: Shastry, R]] | ||
[[Category: Swapna, G V.T | [[Category: Swapna, G V.T]] | ||
[[Category: Xiao, R | [[Category: Xiao, R]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Nonsense regulator]] | [[Category: Nonsense regulator]] | ||
[[Category: | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
