1okk: Difference between revisions
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==Overview== | ==Overview== | ||
Two structurally homologous guanosine triphosphatase (GTPase) domains, interact directly during signal recognition particle (SRP)-mediated, cotranslational targeting of proteins to the membrane. The 2.05 angstrom, structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a, remarkably symmetric heterodimer sequestering a composite active site that, contains two bound nucleotides. The structure explains the coordinate, activation of the two GTPases. Conformational changes coupled to formation, of their extensive interface may function allosterically to signal, formation of the targeting complex to the signal-sequence binding site and, the translocon. We propose that the complex represents a molecular "latch", and that its disengagement is regulated by completion of assembly . | Two structurally homologous guanosine triphosphatase (GTPase) domains, interact directly during signal recognition particle (SRP)-mediated, cotranslational targeting of proteins to the membrane. The 2.05 angstrom, structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a, remarkably symmetric heterodimer sequestering a composite active site that, contains two bound nucleotides. The structure explains the coordinate, activation of the two GTPases. Conformational changes coupled to formation, of their extensive interface may function allosterically to signal, formation of the targeting complex to the signal-sequence binding site and, the translocon. We propose that the complex represents a molecular "latch", and that its disengagement is regulated by completion of assembly of the, GTPase active site. | ||
==About this Structure== | ==About this Structure== | ||
1OKK is a | 1OKK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with SO4, MG, GCP, BZP and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: MNA. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKK OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: srp]] | [[Category: srp]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:31:28 2007'' | ||
