2ctx: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2ctx.jpg|left|200px]] | [[Image:2ctx.jpg|left|200px]] | ||
'''THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION''' | {{Structure | ||
|PDB= 2ctx |SIZE=350|CAPTION= <scene name='initialview01'>2ctx</scene>, resolution 2.4Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
2CTX is a [ | 2CTX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_naja Naja naja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTX OCA]. | ||
==Reference== | ==Reference== | ||
The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution., Betzel C, Lange G, Pal GP, Wilson KS, Maelicke A, Saenger W, J Biol Chem. 1991 Nov 15;266(32):21530-6. PMID:[http:// | The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution., Betzel C, Lange G, Pal GP, Wilson KS, Maelicke A, Saenger W, J Biol Chem. 1991 Nov 15;266(32):21530-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1939183 1939183] | ||
[[Category: Naja naja]] | [[Category: Naja naja]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 21: | Line 30: | ||
[[Category: neurotoxin]] | [[Category: neurotoxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:19:49 2008'' | ||
Revision as of 14:19, 20 March 2008
| |||||||||||||
| 2ctx, resolution 2.4Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE REFINED CRYSTAL STRUCTURE OF ALPHA-COBRATOXIN FROM NAJA NAJA SIAMENSIS AT 2.4-ANGSTROMS RESOLUTION
Overview
The crystal structure of the "long" alpha-neurotoxin alpha-cobratoxin was refined to an R-factor of 19.5% using 3271 x-ray data to 2.4-A resolution. The polypeptide chain forms three loops, I, II, III, knotted together by four disulfide bridges, with the most prominent, loop II, containing another disulfide close to its lower tip. Loop I is stabilized by one beta-turn and two beta-sheet hydrogen bonds; loop II by eight beta-sheet hydrogen bonds, with the tip folded into two distorted right-handed helical turns stabilized by two alpha-helical and two beta-turn hydrogen bonds; and loop III by hydrophobic interactions and one beta-turn. Loop II and one strand of loop III form an antiparallel triple-pleated beta-sheet, and tight anchoring of the Asn63 side chain fixes the tail segment. In the crystal lattice, the alpha-cobratoxin molecules dimerize by beta-sheet formation between strands 53 and 57 of symmetry-related molecules. Because such interactions are found also in a cardiotoxin and alpha-bungarotoxin, this could be of importance for interaction with acetylcholine receptor.
About this Structure
2CTX is a Single protein structure of sequence from Naja naja. Full crystallographic information is available from OCA.
Reference
The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution., Betzel C, Lange G, Pal GP, Wilson KS, Maelicke A, Saenger W, J Biol Chem. 1991 Nov 15;266(32):21530-6. PMID:1939183
Page seeded by OCA on Thu Mar 20 16:19:49 2008
