4fwz: Difference between revisions

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[[Image:4fwz.png|left|200px]]
==Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)==
<StructureSection load='4fwz' size='340' side='right' caption='[[4fwz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FWZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fwx|4fwx]], [[4fwy|4fwy]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9755 Physeter catodon])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fwz RCSB], [http://www.ebi.ac.uk/pdbsum/4fwz PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
No spare Tyr: Rational design of functional enzymes with a high number of turnovers is a challenge, especially those with a complex active site, such as respiratory oxidases. Introducing two His and one Tyr residues into myoglobin resulted in enzymes that reduce O(2) to H(2) O with more than 1000 turnovers (red line, see scheme) and minimal release of reactive oxygen species. The positioning of the Tyr residue is critical for activity.


{{STRUCTURE_4fwz|  PDB=4fwz  |  SCENE=  }}
A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers.,Miner KD, Mukherjee A, Gao YG, Null EL, Petrik ID, Zhao X, Yeung N, Robinson H, Lu Y Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5589-92. doi: 10.1002/anie.201201981., Epub 2012 Apr 26. PMID:22539151<ref>PMID:22539151</ref>


===Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
==About this Structure==
*[[Myoglobin|Myoglobin]]
[[4fwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:022539151</ref><references group="xtra"/>
</StructureSection>
[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
[[Category: Gao, Y G.]]
[[Category: Gao, Y G]]
[[Category: Lu, Y.]]
[[Category: Lu, Y]]
[[Category: Miner, K D.]]
[[Category: Miner, K D]]
[[Category: Petrik, I D.]]
[[Category: Petrik, I D]]
[[Category: Robinson, H.]]
[[Category: Robinson, H]]
[[Category: Globin]]
[[Category: Globin]]
[[Category: Oxidase]]
[[Category: Oxidase]]
[[Category: Transport protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4fwz"