2xxi: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Aldegheri, L | [[Category: Aldegheri, L]] | ||
[[Category: Austin, N E | [[Category: Austin, N E]] | ||
[[Category: Ballantine, S | [[Category: Ballantine, S]] | ||
[[Category: Ballini, E | [[Category: Ballini, E]] | ||
[[Category: Bax, B D | [[Category: Bax, B D]] | ||
[[Category: Bradley, D M | [[Category: Bradley, D M]] | ||
[[Category: Clarke, B P | [[Category: Clarke, B P]] | ||
[[Category: Dalnegro, G | [[Category: Dalnegro, G]] | ||
[[Category: Harries, M | [[Category: Harries, M]] | ||
[[Category: Harris, A J | [[Category: Harris, A J]] | ||
[[Category: Harrison, S A | [[Category: Harrison, S A]] | ||
[[Category: Melarange, R A | [[Category: Melarange, R A]] | ||
[[Category: Mookherjee, C | [[Category: Mookherjee, C]] | ||
[[Category: Mosley, J | [[Category: Mosley, J]] | ||
[[Category: Oliosi, B | [[Category: Oliosi, B]] | ||
[[Category: Smith, K J | [[Category: Smith, K J]] | ||
[[Category: Thewlis, K M | [[Category: Thewlis, K M]] | ||
[[Category: Ward, S E | [[Category: Ward, S E]] | ||
[[Category: Woollard, P M | [[Category: Woollard, P M]] | ||
[[Category: Yusaf, S P | [[Category: Yusaf, S P]] | ||
[[Category: Ampa receptor ligand-binding core]] | [[Category: Ampa receptor ligand-binding core]] | ||
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
