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{{STRUCTURE_4pp8|  PDB=4pp8  |  SCENE=  }}
==Crystal structure of murine NK cell ligand RAE-1 beta in complex with NKG2D==
===Crystal structure of murine NK cell ligand RAE-1 beta in complex with NKG2D===
<StructureSection load='4pp8' size='340' side='right' caption='[[4pp8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
{{ABSTRACT_PUBMED_11825567}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4pp8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jsk 1jsk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PP8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Klrk1, Nkg2d, RAE-1 BETA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), NKG2D, Raet1b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pp8 RCSB], [http://www.ebi.ac.uk/pdbsum/4pp8 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE]] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>  [[http://www.uniprot.org/uniprot/RAE1B_MOUSE RAE1B_MOUSE]] Acts as a ligand for NKG2D.<ref>PMID:10894171</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains. The crystal structure of RAE-1beta was distorted from other MHC homologs and displayed noncanonical disulfide bonds. The loss of any remnant of a peptide binding groove was facilitated by the close approach of the groove-defining helices through a hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex structure resembled the human NKG2D-MICA receptor-ligand complex and further demonstrated the promiscuity of the NKG2D ligand binding site.


==Function==
Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D.,Li P, McDermott G, Strong RK Immunity. 2002 Jan;16(1):77-86. PMID:11825567<ref>PMID:11825567</ref>
[[http://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE]] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>  [[http://www.uniprot.org/uniprot/RAE1B_MOUSE RAE1B_MOUSE]] Acts as a ligand for NKG2D.<ref>PMID:10894171</ref>


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4pp8]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jsk 1jsk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PP8 OCA].
</div>


==Reference==
==See Also==
<ref group="xtra">PMID:011825567</ref><references group="xtra"/><references/>
*[[NK cell receptor|NK cell receptor]]
[[Category: Li, P.]]
== References ==
[[Category: Strong, R K.]]
<references/>
__TOC__
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Li, P]]
[[Category: Strong, R K]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Mhc-i platform]]
[[Category: Mhc-i platform]]
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