2k6q: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[2k6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6Q FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ugm|1ugm]], [[2zjd|2zjd]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ugm|1ugm]], [[2zjd|2zjd]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Map1lc3b, Map1alc3, Map1lc3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Map1lc3b, Map1alc3, Map1lc3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6q RCSB], [http://www.ebi.ac.uk/pdbsum/2k6q PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6q RCSB], [http://www.ebi.ac.uk/pdbsum/2k6q PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MLP3B_RAT MLP3B_RAT]] Probably involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/SQSTM_RAT SQSTM_RAT]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.<ref>PMID:10477520</ref> <ref>PMID:11244088</ref> <ref>PMID:11500922</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Adachi, W | [[Category: Adachi, W]] | ||
[[Category: Fujioka, Y | [[Category: Fujioka, Y]] | ||
[[Category: Inagaki, F | [[Category: Inagaki, F]] | ||
[[Category: Ishii, J | [[Category: Ishii, J]] | ||
[[Category: Kumeta, H | [[Category: Kumeta, H]] | ||
[[Category: Nakatogawa, H | [[Category: Nakatogawa, H]] | ||
[[Category: Noda, N | [[Category: Noda, N]] | ||
[[Category: Ohsumi, Y | [[Category: Ohsumi, Y]] | ||
[[Category: Satoo, K | [[Category: Satoo, K]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Apoptosis inhibitor-apoptosis complex]] | [[Category: Apoptosis inhibitor-apoptosis complex]] | ||
Revision as of 12:21, 25 December 2014
LC3 p62 complex structure
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Rattus norvegicus
- Adachi, W
- Fujioka, Y
- Inagaki, F
- Ishii, J
- Kumeta, H
- Nakatogawa, H
- Noda, N
- Ohsumi, Y
- Satoo, K
- Apoptosis
- Apoptosis inhibitor-apoptosis complex
- Autophagy
- Cytoplasmic vesicle
- Differentiation
- Endosome
- Immune response
- Lc3
- Lipoprotein
- Membrane
- Metal-binding
- Microtubule
- Nucleus
- P62
- Phosphoprotein
- Ubl conjugation pathway
- Zinc-finger
