1x2j: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x2j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X2J FirstGlance]. <br> | <table><tr><td colspan='2'>[[1x2j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X2J FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x2r|1x2r]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x2r|1x2r]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x2j RCSB], [http://www.ebi.ac.uk/pdbsum/1x2j PDBsum], [http://www.topsan.org/Proteins/RSGI/1x2j TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x2j RCSB], [http://www.ebi.ac.uk/pdbsum/1x2j PDBsum], [http://www.topsan.org/Proteins/RSGI/1x2j TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Kang, M I | [[Category: Kang, M I]] | ||
[[Category: Kobayashi, A | [[Category: Kobayashi, A]] | ||
[[Category: Nakamura, Y | [[Category: Nakamura, Y]] | ||
[[Category: Ohta, T | [[Category: Ohta, T]] | ||
[[Category: Ohtsuji, M | [[Category: Ohtsuji, M]] | ||
[[Category: Padmanabhan, B | [[Category: Padmanabhan, B]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Scharlock, M | [[Category: Scharlock, M]] | ||
[[Category: Tong, K I | [[Category: Tong, K I]] | ||
[[Category: Yamamoto, M | [[Category: Yamamoto, M]] | ||
[[Category: Yokoyama, S | [[Category: Yokoyama, S]] | ||
[[Category: Beta propeller]] | [[Category: Beta propeller]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
