4nac: Difference between revisions
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==Crystal Structure of the N-terminal Domain of p15RS== | |||
<StructureSection load='4nac' size='340' side='right' caption='[[4nac]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4nac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAC FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nad|4nad]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P15RS, RPRD1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nac RCSB], [http://www.ebi.ac.uk/pdbsum/4nac PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref> | [[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
<references | [[Category: Jin, Z]] | ||
[[Category: Jin, Z | [[Category: Mei, K]] | ||
[[Category: Mei, K | [[Category: Ren, F]] | ||
[[Category: Ren, F | [[Category: Wang, Y]] | ||
[[Category: Wang, Y | |||
[[Category: Alpha helix]] | [[Category: Alpha helix]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 12:31, 25 December 2014
Crystal Structure of the N-terminal Domain of p15RS
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