1lr1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1lr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1lr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR1 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hns|1hns]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hns|1hns]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hns ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hns ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr1 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/HNS_ECOLI HNS_ECOLI]] A DNA-binding protein implicated in transcriptional repression (silencing) as well as in bacterial chromosome organization. H-NS binds tightly to AT-rich dsDNA, increases its thermal stability and inhibits transcription. Also binds to ssDNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. Plays a role in the thermal control of pili and adhesive curli fimbriae production, by inducing transcription of csgD. Represses the CRISPR-cas promoters, permits only weak transcription of the crRNA precursor; its role is antagonized by LeuO. Subject to transcriptional auto-repression. Binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150.<ref>PMID:7934818</ref> <ref>PMID:11031114</ref> <ref>PMID:17010156</ref> <ref>PMID:20659289</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Driscoll, P C | [[Category: Driscoll, P C]] | ||
[[Category: Eccleston, J | [[Category: Eccleston, J]] | ||
[[Category: Esposito, D | [[Category: Esposito, D]] | ||
[[Category: Haq, I | [[Category: Haq, I]] | ||
[[Category: Harris, R | [[Category: Harris, R]] | ||
[[Category: Higgins, C F | [[Category: Higgins, C F]] | ||
[[Category: Hinton, J C.D | [[Category: Hinton, J C.D]] | ||
[[Category: Ladbury, J E | [[Category: Ladbury, J E]] | ||
[[Category: Mbabaali, A | [[Category: Mbabaali, A]] | ||
[[Category: Ono, S | [[Category: Ono, S]] | ||
[[Category: Petrovic, A | [[Category: Petrovic, A]] | ||
[[Category: Chromatin]] | [[Category: Chromatin]] | ||
[[Category: Coiled-coil]] | [[Category: Coiled-coil]] | ||
