2y3w: Difference between revisions

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[[Image:2y3w.png|left|200px]]
==N-TERMINAL HEAD DOMAIN AND BEGINNING OF COILED COIL DOMAIN OF DANIO RERIO SAS-6==
<StructureSection load='2y3w' size='340' side='right' caption='[[2y3w]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2y3w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3W FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y3v|2y3v]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3w RCSB], [http://www.ebi.ac.uk/pdbsum/2y3w PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SAS6_DANRE SAS6_DANRE]] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.<ref>PMID:21273447</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Centrioles are cylindrical, nine-fold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the N-terminal domain of SAS-6 from zebrafish and show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are likely essential to the structural organization of cartwheel centers.


{{STRUCTURE_2y3w|  PDB=2y3w  |  SCENE=  }}
Structures of SAS-6 Suggest Its Organization in Centrioles.,van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B Science. 2011 Jan 27. PMID:21273447<ref>PMID:21273447</ref>


===N-TERMINAL HEAD DOMAIN AND BEGINNING OF COILED COIL DOMAIN OF DANIO RERIO SAS-6===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_21273447}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2y3w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3W OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:021273447</ref><references group="xtra"/>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Breugel, M Van.]]
[[Category: Breugel, M Van]]
[[Category: Basal body]]
[[Category: Basal body]]
[[Category: Cartwheel]]
[[Category: Cartwheel]]
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