3ixx: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ixx]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXX FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ixx]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXX FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixx RCSB], [http://www.ebi.ac.uk/pdbsum/3ixx PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixx RCSB], [http://www.ebi.ac.uk/pdbsum/3ixx PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q9Q6P4_WNV Q9Q6P4_WNV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] [[http://www.uniprot.org/uniprot/Q9WHD2_WNV Q9WHD2_WNV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: West nile virus]] | [[Category: West nile virus]] | ||
[[Category: Cherrier, M V | [[Category: Cherrier, M V]] | ||
[[Category: Chipman, P R | [[Category: Chipman, P R]] | ||
[[Category: Diamond, M S | [[Category: Diamond, M S]] | ||
[[Category: Fremont, D H | [[Category: Fremont, D H]] | ||
[[Category: Holdaway, H A | [[Category: Holdaway, H A]] | ||
[[Category: Kaufmann, B | [[Category: Kaufmann, B]] | ||
[[Category: Kostyuchenko, V A | [[Category: Kostyuchenko, V A]] | ||
[[Category: Kuhn, R J | [[Category: Kuhn, R J]] | ||
[[Category: Lok, S M | [[Category: Lok, S M]] | ||
[[Category: Nelson, C A | [[Category: Nelson, C A]] | ||
[[Category: Nybakken, G E | [[Category: Nybakken, G E]] | ||
[[Category: Rossmann, M G | [[Category: Rossmann, M G]] | ||
[[Category: Warren, J T | [[Category: Warren, J T]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: E53]] | [[Category: E53]] | ||
| Line 60: | Line 62: | ||
[[Category: Virion]] | [[Category: Virion]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
[[Category: Wnv]] | [[Category: Wnv]] | ||
