2j0v: Difference between revisions
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==Overview== | ==Overview== | ||
Arabidopsis thaliana RAC/ROP GTPases constitute a plant specific Rho, GTPase family in the RAS superfamily, which has been implicated in, numerous pivotal signalling cascades in plants. Research has shown that, plants in some cases have evolved different modes of regulating Rho GTPase, activity as compared to the equivalent systems in animals and yeast. In, order to gain structural insight into plant signaling at the molecular, level, we have determined the first crystal structure of a RAC-like GTPase, belonging to the RAS superfamily from the plant kingdom. The structure of, AtRAC7/ROP9 bound to GDP was solved at a resolution of 1.78 A. We have, found that the structure of plant Rho GTPases is based upon a conserved, G-domain architecture, but structural differences were found . | Arabidopsis thaliana RAC/ROP GTPases constitute a plant specific Rho, GTPase family in the RAS superfamily, which has been implicated in, numerous pivotal signalling cascades in plants. Research has shown that, plants in some cases have evolved different modes of regulating Rho GTPase, activity as compared to the equivalent systems in animals and yeast. In, order to gain structural insight into plant signaling at the molecular, level, we have determined the first crystal structure of a RAC-like GTPase, belonging to the RAS superfamily from the plant kingdom. The structure of, AtRAC7/ROP9 bound to GDP was solved at a resolution of 1.78 A. We have, found that the structure of plant Rho GTPases is based upon a conserved, G-domain architecture, but structural differences were found concerning, the insert region and switch II region of the protein. | ||
==About this Structure== | ==About this Structure== | ||
2J0V is a | 2J0V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with MG and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0V OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: rop9]] | [[Category: rop9]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:36:26 2007'' | ||
