3ptr: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ptr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PTR FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ptr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PTR FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pu3|3pu3]], [[3pu8|3pu8]], [[3pua|3pua]], [[3pus|3pus]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pu3|3pu3]], [[3pu8|3pu8]], [[3pua|3pua]], [[3pus|3pus]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHF2, KIAA0662 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PHF2, KIAA0662 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ptr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ptr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ptr RCSB], [http://www.ebi.ac.uk/pdbsum/3ptr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ptr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ptr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ptr RCSB], [http://www.ebi.ac.uk/pdbsum/3ptr PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PHF2_HUMAN PHF2_HUMAN]] Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.<ref>PMID:21532585</ref> <ref>PMID:20129925</ref> <ref>PMID:21167174</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural Basis for Human PHF2 Jumonji Domain Interaction with Metal Ions.,Horton JR, Upadhyay AK, Hashimoto H, Zhang X, Cheng X J Mol Biol. 2010 Dec 15. PMID:21167174<ref>PMID:21167174</ref> | Structural Basis for Human PHF2 Jumonji Domain Interaction with Metal Ions.,Horton JR, Upadhyay AK, Hashimoto H, Zhang X, Cheng X J Mol Biol. 2010 Dec 15. PMID:21167174<ref>PMID:21167174</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cheng, X | [[Category: Cheng, X]] | ||
[[Category: Hashimoto, H | [[Category: Hashimoto, H]] | ||
[[Category: Horton, J R | [[Category: Horton, J R]] | ||
[[Category: Upadhyay, A K | [[Category: Upadhyay, A K]] | ||
[[Category: Zhang, X | [[Category: Zhang, X]] | ||
[[Category: Alpha-ketoglutarate-fe2+ dependent dioxygenase]] | [[Category: Alpha-ketoglutarate-fe2+ dependent dioxygenase]] | ||
[[Category: Histone tail binding protein]] | [[Category: Histone tail binding protein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
