3glu: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3glu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3glu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3glu RCSB], [http://www.ebi.ac.uk/pdbsum/3glu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3glu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3glu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3glu RCSB], [http://www.ebi.ac.uk/pdbsum/3glu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SIRT3_HUMAN SIRT3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> [[http://www.uniprot.org/uniprot/ACS2L_HUMAN ACS2L_HUMAN]] Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).<ref>PMID:16788062</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
