1snf: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1snf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNF FirstGlance]. <br> | <table><tr><td colspan='2'>[[1snf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SNF FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mq7|1mq7]], [[1smc|1smc]], [[1slh|1slh]], [[1sjn|1sjn]], [[1six|1six]], [[1sm8|1sm8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mq7|1mq7]], [[1smc|1smc]], [[1slh|1slh]], [[1sjn|1sjn]], [[1six|1six]], [[1sm8|1sm8]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1snf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1snf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1snf RCSB], [http://www.ebi.ac.uk/pdbsum/1snf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1snf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1snf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1snf RCSB], [http://www.ebi.ac.uk/pdbsum/1snf PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: DUTP diphosphatase]] | [[Category: DUTP diphosphatase]] | ||
[[Category: Cascio, D | [[Category: Cascio, D]] | ||
[[Category: Chan, S | [[Category: Chan, S]] | ||
[[Category: Cho, U S | [[Category: Cho, U S]] | ||
[[Category: Eisenberg, D | [[Category: Eisenberg, D]] | ||
[[Category: Kim, C Y | [[Category: Kim, C Y]] | ||
[[Category: Kim, M Y | [[Category: Kim, M Y]] | ||
[[Category: Krupka, H | [[Category: Krupka, H]] | ||
[[Category: Lekin, T | [[Category: Lekin, T]] | ||
[[Category: Naranjo, C M | [[Category: Naranjo, C M]] | ||
[[Category: Park, M S | [[Category: Park, M S]] | ||
[[Category: Pashkov, I | [[Category: Pashkov, I]] | ||
[[Category: Perry, J L | [[Category: Perry, J L]] | ||
[[Category: Rogers, Y C | [[Category: Rogers, Y C]] | ||
[[Category: Sawaya, M R | [[Category: Sawaya, M R]] | ||
[[Category: Segelke, B | [[Category: Segelke, B]] | ||
[[Category: So, M | [[Category: So, M]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Terwilliger, T C | [[Category: Terwilliger, T C]] | ||
[[Category: Waldo, G S | [[Category: Waldo, G S]] | ||
[[Category: Yeates, T O | [[Category: Yeates, T O]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Jelly-roll]] | [[Category: Jelly-roll]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Tbsgc]] | [[Category: Tbsgc]] | ||
