2mhs: Difference between revisions
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<StructureSection load='2mhs' size='340' side='right' caption='[[2mhs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2mhs' size='340' side='right' caption='[[2mhs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. | <table><tr><td colspan='2'>[[2mhs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHS FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [http://www.ebi.ac.uk/pdbsum/2mhs PDBsum]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhs RCSB], [http://www.ebi.ac.uk/pdbsum/2mhs PDBsum]</span></td></tr> | </table> | ||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 12: | Line 13: | ||
High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref> | High-quality NMR structure of human anti-apoptotic protein domain mcl-1(171-327) for cancer drug design.,Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T PLoS One. 2014 May 2;9(5):e96521. doi: 10.1371/journal.pone.0096521. eCollection , 2014. PMID:24789074<ref>PMID:24789074</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Bcl-2|Bcl-2]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Aoki, K | [[Category: Aoki, K]] | ||
[[Category: Lewis, J | [[Category: Lewis, J]] | ||
[[Category: Liu, G | [[Category: Liu, G]] | ||
[[Category: Poppe, L | [[Category: Poppe, L]] | ||
[[Category: Szyperski, T | [[Category: Szyperski, T]] | ||
[[Category: Yamane, H | [[Category: Yamane, H]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bcl-2 family]] | [[Category: Bcl-2 family]] | ||
