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{{STRUCTURE_4iqy|  PDB=4iqy  |  SCENE=  }}
==Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2==
===Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2===
<StructureSection load='4iqy' size='340' side='right' caption='[[4iqy]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
{{ABSTRACT_PUBMED_23474712}}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4iqy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQY FirstGlance]. <br>
==Function==
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MACROD2, C20orf133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqy RCSB], [http://www.ebi.ac.uk/pdbsum/4iqy PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MACD2_HUMAN MACD2_HUMAN]] Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.<ref>PMID:21257746</ref>   
[[http://www.uniprot.org/uniprot/MACD2_HUMAN MACD2_HUMAN]] Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.<ref>PMID:21257746</ref>   
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD(+) to transfer either single or multiple ADP-ribose (ADPr) moieties onto distinct amino acid substrates, often in response to DNA damage or other stresses. Poly-ADPr-glycohydrolase readily reverses poly-ADP-ribosylation induced by the DNA-damage sensor PARP1 and other enzymes, but it does not remove the most proximal ADPr linked to the target amino acid. Searches for enzymes capable of fully reversing cellular mono-ADP-ribosylation back to the unmodified state have proved elusive, which leaves a gap in the understanding of this modification. Here, we identify a family of macrodomain enzymes present in viruses, yeast and animals that reverse cellular ADP-ribosylation by acting on mono-ADP-ribosylated substrates. Our discoveries establish the complete reversibility of PARP-catalyzed cellular ADP-ribosylation as a regulatory modification.


==About this Structure==
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.,Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG Nat Struct Mol Biol. 2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar, 10. PMID:23474712<ref>PMID:23474712</ref>
[[4iqy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQY OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Golia, B.]]
[[Category: Golia, B]]
[[Category: Hassler, M.]]
[[Category: Hassler, M]]
[[Category: Jankevicius, G.]]
[[Category: Jankevicius, G]]
[[Category: Ladurner, A G.]]
[[Category: Ladurner, A G]]
[[Category: Rybin, V.]]
[[Category: Rybin, V]]
[[Category: Timinszky, G.]]
[[Category: Timinszky, G]]
[[Category: Zacharias, M.]]
[[Category: Zacharias, M]]
[[Category: Adp-ribose binding]]
[[Category: Adp-ribose binding]]
[[Category: Adp-ribosylation]]
[[Category: Adp-ribosylation]]
Retrieved from "https://proteopedia.org/4iqy"