1ss2: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT]] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Barlow, P N | [[Category: Barlow, P N]] | ||
[[Category: Blein, S | [[Category: Blein, S]] | ||
[[Category: Smith, B O | [[Category: Smith, B O]] | ||
[[Category: Uhrin, D | [[Category: Uhrin, D]] | ||
[[Category: White, J H | [[Category: White, J H]] | ||
[[Category: Ccp module]] | [[Category: Ccp module]] | ||
[[Category: Cis-trans isomerisation]] | [[Category: Cis-trans isomerisation]] | ||
