1ugn: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ugn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g0x|1g0x]], [[1ufu|1ufu]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g0x|1g0x]], [[1ufu|1ufu]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugn RCSB], [http://www.ebi.ac.uk/pdbsum/1ugn PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Amano, K | [[Category: Amano, K]] | ||
[[Category: Kohda, D | [[Category: Kohda, D]] | ||
[[Category: Kuroki, K | [[Category: Kuroki, K]] | ||
[[Category: Maenaka, K | [[Category: Maenaka, K]] | ||
[[Category: Rasubala, L | [[Category: Rasubala, L]] | ||
[[Category: Shiroishi, M | [[Category: Shiroishi, M]] | ||
[[Category: Tokunaga, K | [[Category: Tokunaga, K]] | ||
[[Category: Tsuchiya, N | [[Category: Tsuchiya, N]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immunoglobulin-like fold]] | [[Category: Immunoglobulin-like fold]] | ||
