4qbm: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qbm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qbm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBM FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qc1|4qc1]], [[4qc3|4qc3]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qc1|4qc1]], [[4qc3|4qc3]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qbm RCSB], [http://www.ebi.ac.uk/pdbsum/4qbm PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qbm RCSB], [http://www.ebi.ac.uk/pdbsum/4qbm PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Filippakopoulos, P | [[Category: Filippakopoulos, P]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Nunez-Alonso, G | [[Category: Nunez-Alonso, G]] | ||
[[Category: Picaud, S | [[Category: Picaud, S]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tallant, C | [[Category: Tallant, C]] | ||
[[Category: Williams, E | [[Category: Williams, E]] | ||
[[Category: Bromodomain]] | [[Category: Bromodomain]] | ||
[[Category: Bromodomain adjacent to zinc finger domain protein 2a]] | [[Category: Bromodomain adjacent to zinc finger domain protein 2a]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Tip5]] | [[Category: Tip5]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription termination factor i-interacting protein 5]] | [[Category: Transcription termination factor i-interacting protein 5]] | ||
