4twk: Difference between revisions

Revision as of 17:41, 25 December 2014

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Structural highlights

4twk is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	37X, K, MG, NAG
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[KCNK2_HUMAN] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.^[1] ^[2] ^[3] Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).^[4] ^[5] ^[6]

References

↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:https://dx.doi.org/10.1007/s00424-013-1384-z
↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:https://dx.doi.org/10.1038/87434
↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:https://dx.doi.org/10.1007/s00424-013-1384-z
↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:https://dx.doi.org/10.1038/87434

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OCA

[1] Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345

[2] Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:https://dx.doi.org/10.1007/s00424-013-1384-z

[3] Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:https://dx.doi.org/10.1038/87434

[4] Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345

[5] Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:https://dx.doi.org/10.1007/s00424-013-1384-z

[6] Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:https://dx.doi.org/10.1038/87434

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[4twk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN]] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>   Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Ang, J H.]]
+[[Category: Ang, J H]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Berridge, G.]]
+[[Category: Berridge, G]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Burgess-Brown, N A.]]
+[[Category: Burgess-Brown, N A]]
-[[Category: Bushell, S R.]]
+[[Category: Bushell, S R]]
-[[Category: Carpenter, E P.]]
+[[Category: Carpenter, E P]]
-[[Category: Chalk, R.]]
+[[Category: Chalk, R]]
-[[Category: Chu, A.]]
+[[Category: Chu, A]]
-[[Category: Delft, F von.]]
+[[Category: Delft, F von]]
-[[Category: Dong, L.]]
+[[Category: Dong, L]]
-[[Category: Dong, Y Y.]]
+[[Category: Dong, Y Y]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Faust, B.]]
+[[Category: Faust, B]]
-[[Category: Goubin, S.]]
+[[Category: Goubin, S]]
-[[Category: Grieben, M.]]
+[[Category: Grieben, M]]
-[[Category: Kupinska, K.]]
+[[Category: Kupinska, K]]
-[[Category: Mackenzie, A.]]
+[[Category: Mackenzie, A]]
-[[Category: Mukhopadhyay, S.]]
+[[Category: Mukhopadhyay, S]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike, A C.W]]
-[[Category: Quigley, A.]]
+[[Category: Quigley, A]]
-[[Category: Shintre, C A.]]
+[[Category: Shintre, C A]]
-[[Category: Shrestha, L.]]
+[[Category: Shrestha, L]]
-[[Category: Strain-Damerell, C.]]
+[[Category: Strain-Damerell, C]]
-[[Category: Tessitore, A.]]
+[[Category: Tessitore, A]]
-[[Category: Wang, D.]]
+[[Category: Wang, D]]
 [[Category: Ion channel]]
 [[Category: K2p]]
 [[Category: Membrane protein]]
 [[Category: Transport protein]]

4twk: Difference between revisions

Revision as of 17:41, 25 December 2014

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Structural highlights

Function

References

Contents

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