2tmp: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2tmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2TMP FirstGlance]. <br> | <table><tr><td colspan='2'>[[2tmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2TMP FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2tmp RCSB], [http://www.ebi.ac.uk/pdbsum/2tmp PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2tmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2tmp RCSB], [http://www.ebi.ac.uk/pdbsum/2tmp PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Carr, M D | [[Category: Carr, M D]] | ||
[[Category: Feeney, J | [[Category: Feeney, J]] | ||
[[Category: Freedman, R B | [[Category: Freedman, R B]] | ||
[[Category: Frenkiel, T A | [[Category: Frenkiel, T A]] | ||
[[Category: Muskett, F W | [[Category: Muskett, F W]] | ||
[[Category: Williamson, R A | [[Category: Williamson, R A]] | ||
[[Category: Metalloprotease inhibitor]] | [[Category: Metalloprotease inhibitor]] | ||
[[Category: Metalloproteinase inhibitor]] | [[Category: Metalloproteinase inhibitor]] | ||
[[Category: Ob protein fold]] | [[Category: Ob protein fold]] | ||
[[Category: Timp]] | [[Category: Timp]] | ||
