2kr9: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kr9 RCSB], [http://www.ebi.ac.uk/pdbsum/2kr9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kr9 RCSB], [http://www.ebi.ac.uk/pdbsum/2kr9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KALRN_RAT KALRN_RAT]] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.<ref>PMID:10692441</ref> <ref>PMID:11606631</ref> <ref>PMID:15950621</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Gorbatyuk, V Y | [[Category: Gorbatyuk, V Y]] | ||
[[Category: Hoch, J C | [[Category: Hoch, J C]] | ||
[[Category: Schiller, M R | [[Category: Schiller, M R]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
[[Category: Dbl-family gef]] | [[Category: Dbl-family gef]] | ||
Revision as of 17:56, 25 December 2014
Kalirin DH1 NMR structure
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