4f5w: Difference between revisions
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==Crystal structure of ligand free human STING CTD== | |||
=== | <StructureSection load='4f5w' size='340' side='right' caption='[[4f5w]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4f5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F5W FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f5y|4f5y]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f5w RCSB], [http://www.ebi.ac.uk/pdbsum/4f5w PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
STING functions as both an adaptor protein signaling cytoplasmic double-stranded DNA and a direct immunosensor of cyclic diguanylate monophosphate (c-di-GMP). The crystal structures of the C-terminal domain of human STING (STING(CTD)) and its complex with c-di-GMP reveal how STING recognizes c-di-GMP. In response to c-di-GMP binding, two surface loops, which serve as a gate and latch of the cleft formed by the dimeric STING(CTD), undergo rearrangements to interact with the ligand. | |||
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.,Shang G, Zhu D, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L Nat Struct Mol Biol. 2012 Jun 24;19(7):725-7. doi: 10.1038/nsmb.2332. PMID:22728660<ref>PMID:22728660</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Stimulator of interferon genes|Stimulator of interferon genes]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gu, L | [[Category: Gu, L]] | ||
[[Category: Li, N | [[Category: Li, N]] | ||
[[Category: Liu, C | [[Category: Liu, C]] | ||
[[Category: Lu, D | [[Category: Lu, D]] | ||
[[Category: Shang, G | [[Category: Shang, G]] | ||
[[Category: Xu, S | [[Category: Xu, S]] | ||
[[Category: Yu, Q | [[Category: Yu, Q]] | ||
[[Category: Zhang, J | [[Category: Zhang, J]] | ||
[[Category: Zhao, Y | [[Category: Zhao, Y]] | ||
[[Category: Zhu, C | [[Category: Zhu, C]] | ||
[[Category: Zhu, D | [[Category: Zhu, D]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
[[Category: Innate immunity human sting]] | [[Category: Innate immunity human sting]] | ||
Revision as of 18:31, 25 December 2014
Crystal structure of ligand free human STING CTD
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