2es4: Difference between revisions
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[[Image:2es4.gif|left|200px]] | [[Image:2es4.gif|left|200px]] | ||
'''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase''' | {{Structure | ||
|PDB= 2es4 |SIZE=350|CAPTION= <scene name='initialview01'>2es4</scene>, resolution 1.85Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] | |||
|GENE= lifO, lipB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=337 Burkholderia glumae]) | |||
}} | |||
'''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2ES4 is a [ | 2ES4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Burkholderia_glumae Burkholderia glumae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES4 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:[http:// | Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16518399 16518399] | ||
[[Category: Burkholderia glumae]] | [[Category: Burkholderia glumae]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: triacylglycerol hydrolase]] | [[Category: triacylglycerol hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:43:51 2008'' | ||
Revision as of 14:43, 20 March 2008
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| 2es4, resolution 1.85Å | |||||||||||||
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| Ligands: | CA and IOD | ||||||||||||
| Gene: | lifO, lipB (Burkholderia glumae) | ||||||||||||
| Activity: | Triacylglycerol lipase, with EC number 3.1.1.3 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
Overview
Secretion via the type II secretion pathway in Gram-negative bacteria often relies crucially on steric chaperones in the periplasm. Here, we report the crystal structure of the soluble form of a lipase-specific foldase (Lif) from Burkholderia glumae in complex with its cognate lipase. The structure reveals how Lif uses a novel alpha-helical scaffold to embrace lipase, thereby creating an unusually extensive folding platform.
About this Structure
2ES4 is a Protein complex structure of sequences from Burkholderia glumae. Full crystallographic information is available from OCA.
Reference
Structure of a membrane-based steric chaperone in complex with its lipase substrate., Pauwels K, Lustig A, Wyns L, Tommassen J, Savvides SN, Van Gelder P, Nat Struct Mol Biol. 2006 Apr;13(4):374-5. Epub 2006 Mar 5. PMID:16518399
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