2f16: Difference between revisions

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[[Image:2f16.gif|left|200px]]~~<br /><applet load~~="2f16~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2f16.gif|left|200px]]

~~caption="~~2f16, resolution 2.8Å" />

'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''~~<br />~~

{{Structure

|PDB= 2f16 |SIZE=350|CAPTION= <scene name='initialview01'>2f16</scene>, resolution 2.8Å

|SITE=

|LIGAND= <scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1]

|GENE=

}}

'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''

==Overview==

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==About this Structure==

2F16 is a [~~http://en.wikipedia.org/wiki/Protein_complex~~ Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=BO2:'>BO2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.~~php4?ecno=3.4.25.1 3.4.25.1]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F16 OCA].

2F16 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F16 OCA].

==Reference==

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome., Groll M, Berkers CR, Ploegh HL, Ovaa H, Structure. 2006 Mar;14(3):451-6. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~16531229 16531229]

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome., Groll M, Berkers CR, Ploegh HL, Ovaa H, Structure. 2006 Mar;14(3):451-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16531229 16531229]

[[Category: Proteasome endopeptidase complex]]

[[Category: Protein complex]]

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[[Category: Groll, M.]]

[[Category: BO2]]

[[Category: beta-sandwich flanked by ~~helices~~]]

[[Category: beta-sandwich flanked by helice]]

[[Category: complex structure covalently bound to the synthetic inihibtor bortezomib]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 17~~:16:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:46:49 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2f16.gif|left|200px]]<br /><applet load="2f16" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2f16.gif|left|200px]]
-caption="2f16, resolution 2.8&Aring;" />
-'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''<br />
+ {{Structure
+|PDB= 2f16 |SIZE=350|CAPTION= <scene name='initialview01'>2f16</scene>, resolution 2.8&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1]
+|GENE=
+}}
+'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-F16 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=BO2:'>BO2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F16 OCA].
+F16 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F16 OCA].
 ==Reference==
-Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome., Groll M, Berkers CR, Ploegh HL, Ovaa H, Structure. 2006 Mar;14(3):451-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16531229 16531229]
+Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome., Groll M, Berkers CR, Ploegh HL, Ovaa H, Structure. 2006 Mar;14(3):451-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16531229 16531229]
 [[Category: Proteasome endopeptidase complex]]
 [[Category: Protein complex]]
@@ Line 16: / Line 25: @@
 [[Category: Groll, M.]]
 [[Category: BO2]]
-[[Category: beta-sandwich flanked by helices]]
+[[Category: beta-sandwich flanked by helice]]
 [[Category: complex structure covalently bound to the synthetic inihibtor bortezomib]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:16:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:46:49 2008''