2vrd: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vrd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uw2 1uw2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRD FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vrd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uw2 1uw2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VRD FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vrd RCSB], [http://www.ebi.ac.uk/pdbsum/2vrd PDBsum], [http://www.topsan.org/Proteins/RSGI/2vrd TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vrd RCSB], [http://www.ebi.ac.uk/pdbsum/2vrd PDBsum], [http://www.topsan.org/Proteins/RSGI/2vrd TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RU1C_HUMAN RU1C_HUMAN]] Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.<ref>PMID:2136774</ref> <ref>PMID:1826349</ref> <ref>PMID:8798632</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hernandez, H | [[Category: Hernandez, H]] | ||
[[Category: Muto, Y | [[Category: Muto, Y]] | ||
[[Category: Nagai, K | [[Category: Nagai, K]] | ||
[[Category: Neuhaus, D | [[Category: Neuhaus, D]] | ||
[[Category: Oubridge, C | [[Category: Oubridge, C]] | ||
[[Category: Pomeranz-Krummel, D | [[Category: Pomeranz-Krummel, D]] | ||
[[Category: Robinson, C | [[Category: Robinson, C]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nuclear protein]] | [[Category: Nuclear protein]] | ||
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[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Ribonucleoprotein]] | [[Category: Ribonucleoprotein]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Rna-binding]] | [[Category: Rna-binding]] | ||
[[Category: Rna-binding protein]] | [[Category: Rna-binding protein]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Spliceosomal protein]] | [[Category: Spliceosomal protein]] | ||
[[Category: U1 snrnp]] | [[Category: U1 snrnp]] | ||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
