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{{STRUCTURE_4n5u|  PDB=4n5u  |  SCENE=  }}
==Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]==
===Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]===
<StructureSection load='4n5u' size='340' side='right' caption='[[4n5u]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4n5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N5U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAR, PTPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n5u RCSB], [http://www.ebi.ac.uk/pdbsum/4n5u PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN]] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref>  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>   
[[http://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN]] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref>  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>   
 
== References ==
==About this Structure==
<references/>
[[4n5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5U OCA].
__TOC__
 
</StructureSection>
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Attonito, J.]]
[[Category: Attonito, J]]
[[Category: Banu, R.]]
[[Category: Banu, R]]
[[Category: Bhosle, R.]]
[[Category: Bhosle, R]]
[[Category: Calarese, D A.]]
[[Category: Calarese, D A]]
[[Category: Casadevall, A.]]
[[Category: Casadevall, A]]
[[Category: Celikgil, A.]]
[[Category: Celikgil, A]]
[[Category: Chamala, S.]]
[[Category: Chamala, S]]
[[Category: Chan, M K.]]
[[Category: Chan, M K]]
[[Category: Chowdhury, S.]]
[[Category: Chowdhury, S]]
[[Category: Fiser, A.]]
[[Category: Fiser, A]]
[[Category: Garforth, S J.]]
[[Category: Garforth, S J]]
[[Category: Glenn, A S.]]
[[Category: Glenn, A S]]
[[Category: Hillerich, B.]]
[[Category: Hillerich, B]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
[[Category: Khafizov, K.]]
[[Category: Khafizov, K]]
[[Category: Kumar, P R.]]
[[Category: Kumar, P R]]
[[Category: Love, J D.]]
[[Category: Love, J D]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Structural genomic]]
[[Category: Patel, H.]]
[[Category: Patel, H]]
[[Category: Patel, R.]]
[[Category: Patel, R]]
[[Category: Seidel, R D.]]
[[Category: Seidel, R D]]
[[Category: Smith, B.]]
[[Category: Smith, B]]
[[Category: Stead, M.]]
[[Category: Stead, M]]
[[Category: Toro, R.]]
[[Category: Toro, R]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Internal fn3 domain]]
[[Category: Internal fn3 domain]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]

Revision as of 21:02, 25 December 2014

Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]

4n5u, resolution 1.46Å

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