2fgu: Difference between revisions

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[[Image:2fgu.gif|left|200px]]<br /><applet load="2fgu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fgu.gif|left|200px]]
caption="2fgu, resolution 2.00&Aring;" />
 
'''X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.'''<br />
{{Structure
|PDB= 2fgu |SIZE=350|CAPTION= <scene name='initialview01'>2fgu</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=QNC:2-CARBONYLQUINOLINE'>QNC</scene> and <scene name='pdbligand=DIQ:2-METHYL-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID'>DIQ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FGU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=QNC:'>QNC</scene> and <scene name='pdbligand=DIQ:'>DIQ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGU OCA].  
2FGU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FGU OCA].  


==Reference==
==Reference==
Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity., Foulkes JE, Prabu-Jeyabalan M, Cooper D, Henderson GJ, Harris J, Swanstrom R, Schiffer CA, J Virol. 2006 Jul;80(14):6906-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16809296 16809296]
Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity., Foulkes JE, Prabu-Jeyabalan M, Cooper D, Henderson GJ, Harris J, Swanstrom R, Schiffer CA, J Virol. 2006 Jul;80(14):6906-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16809296 16809296]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: QNC]]
[[Category: QNC]]
[[Category: drug resistance]]
[[Category: drug resistance]]
[[Category: enzyme kinetics]]
[[Category: enzyme kinetic]]
[[Category: hiv protease]]
[[Category: hiv protease]]
[[Category: protein structure]]
[[Category: protein structure]]
[[Category: sequence conservation]]
[[Category: sequence conservation]]


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