3k3f

Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris

spinqualitylabelsall models 3k3f, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3k3f is a 1 chain structure with sequence from Desulfovibrio vulgaris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AU Related: 3k3g Gene: DVU_1160 (Desulfovibrio vulgaris) Resources: FirstGlance, OCA, RCSB, PDBsum Function [Q72CX3_DESVH] Urea channel that facilitates transmembrane urea transport down a concentration gradient. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Urea is highly concentrated in the mammalian kidney to produce the osmotic gradient necessary for water re-absorption. Free diffusion of urea across cell membranes is slow owing to its high polarity, and specialized urea transporters have evolved to achieve rapid and selective urea permeation. Here we present the 2.3 A structure of a functional urea transporter from the bacterium Desulfovibrio vulgaris. The transporter is a homotrimer, and each subunit contains a continuous membrane-spanning pore formed by the two homologous halves of the protein. The pore contains a constricted selectivity filter that can accommodate several dehydrated urea molecules in single file. Backbone and side-chain oxygen atoms provide continuous coordination of urea as it progresses through the filter, and well-placed alpha-helix dipoles provide further compensation for dehydration energy. These results establish that the urea transporter operates by a channel-like mechanism and reveal the physical and chemical basis of urea selectivity. Crystal structure of a bacterial homologue of the kidney urea transporter.,Levin EJ, Quick M, Zhou M Nature. 2009 Dec 10;462(7274):757-61. Epub . PMID:19865084 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Urea transporter

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