2flb: Difference between revisions

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[[Image:2flb.gif|left|200px]]<br /><applet load="2flb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2flb.gif|left|200px]]
caption="2flb, resolution 1.95&Aring;" />
 
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''<br />
{{Structure
|PDB= 2flb |SIZE=350|CAPTION= <scene name='initialview01'>2flb</scene>, resolution 1.95&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=6NH:2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>6NH</scene>
|ACTIVITY=
|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=6NH:'>6NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].  
2FLB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA].  


==Reference==
==Reference==
Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16487703 16487703]
Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16487703 16487703]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: short hydrogen bond-mediated]]
[[Category: short hydrogen bond-mediated]]


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