2azh: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2azh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZH FirstGlance]. <br> | <table><tr><td colspan='2'>[[2azh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZH FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xjs|1xjs]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xjs|1xjs]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YURV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YURV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azh RCSB], [http://www.ebi.ac.uk/pdbsum/2azh PDBsum], [http://www.topsan.org/Proteins/NESGC/2azh TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azh RCSB], [http://www.ebi.ac.uk/pdbsum/2azh PDBsum], [http://www.topsan.org/Proteins/NESGC/2azh TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NIFU_BACSU NIFU_BACSU]] Its function is controversial. Has been generally assumed to be an iron-sulfur cluster assembly scaffold protein (PubMed=20097860, PubMed:21236255), but more recent evidence suggest it is a sulfurtransferase rather than a scaffold assembly protein (PubMed:24321018). Has been shown to bind low levels of a labile, air-sensitive Fe-S cluster; this can be assembled under anaerobic conditions from FeCl(3) and Li(2)S. Has been shown to be able to transfer this Fe-S cluster to an acceptor protein. Stimulates the cysteine desulfurase activity of SufS, for which it acts as a second substrate. Alkylation eliminates its ability to stimulate SufS. A mixture of SufS, SufU, Fra and L-cysteine is able to reconstitute Fe-S clusters on apo-aconitase (citB), reconstituting aconitase activity.<ref>PMID:20822158</ref> <ref>PMID:20097860</ref> <ref>PMID:21744456</ref> <ref>PMID:24321018</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Aramini, J M | [[Category: Aramini, J M]] | ||
[[Category: Cort, J R | [[Category: Cort, J R]] | ||
[[Category: Kennedy, M A | [[Category: Kennedy, M A]] | ||
[[Category: Kornhaber, G J | [[Category: Kornhaber, G J]] | ||
[[Category: Montelione, G T | [[Category: Montelione, G T]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Ramelot, T A | [[Category: Ramelot, T A]] | ||
[[Category: Swapna, G V.T | [[Category: Swapna, G V.T]] | ||
[[Category: Autostructure]] | [[Category: Autostructure]] | ||
[[Category: Iron-sulfur]] | [[Category: Iron-sulfur]] | ||
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[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Nifu-like]] | [[Category: Nifu-like]] | ||
[[Category: | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Sr17]] | [[Category: Sr17]] | ||
[[Category: Sufu]] | [[Category: Sufu]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
