2fmn: Difference between revisions

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[[Image:2fmn.gif|left|200px]]<br /><applet load="2fmn" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fmn.gif|left|200px]]
caption="2fmn, resolution 2.05&Aring;" />
 
'''Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887'''<br />
{{Structure
|PDB= 2fmn |SIZE=350|CAPTION= <scene name='initialview01'>2fmn</scene>, resolution 2.05&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene> and <scene name='pdbligand=4HF:N-[(5-{2-[(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPYRIDO[2,3-D]PYRIMIDIN-6-YL]ETHYL}-2-THIENYL)CARBONYL]-L-GLUTAMIC ACID'>4HF</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20]
|GENE= metF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FMN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=4HF:'>4HF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase_(NAD(P)H) Methylenetetrahydrofolate reductase (NAD(P)H)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.20 1.5.1.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMN OCA].  
2FMN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMN OCA].  


==Reference==
==Reference==
Structural perturbations in the Ala --&gt; Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation., Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML, Biochemistry. 2006 Apr 18;45(15):4808-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16605249 16605249]
Structural perturbations in the Ala --&gt; Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation., Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML, Biochemistry. 2006 Apr 18;45(15):4808-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16605249 16605249]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Methylenetetrahydrofolate reductase (NAD(P)H)]]
[[Category: Methylenetetrahydrofolate reductase (NAD(P)H)]]
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[[Category: tim barrel]]
[[Category: tim barrel]]


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