2fns: Difference between revisions

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[[Image:2fns.gif|left|200px]]<br /><applet load="2fns" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fns.gif|left|200px]]
caption="2fns, resolution 1.85&Aring;" />
 
'''Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.'''<br />
{{Structure
|PDB= 2fns |SIZE=350|CAPTION= <scene name='initialview01'>2fns</scene>, resolution 1.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FNS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FNS OCA].  
2FNS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FNS OCA].  


==Reference==
==Reference==
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate., Prabu-Jeyabalan M, Nalivaika EA, Romano K, Schiffer CA, J Virol. 2006 Apr;80(7):3607-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16537628 16537628]
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate., Prabu-Jeyabalan M, Nalivaika EA, Romano K, Schiffer CA, J Virol. 2006 Apr;80(7):3607-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16537628 16537628]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: substrate recognition]]
[[Category: substrate recognition]]


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