Glucuronidase: Difference between revisions
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This tutorial illustrates the quaternary structures of the human and ''E. coli'' β-glucuronidase enzyme. | This tutorial illustrates the quaternary structures of the human and ''E. coli'' β-glucuronidase enzyme. | ||
__TOC__ | |||
== Function == | == Function == | ||
'''β-glucuronidase''' is a ubiquitous enzyme that catalyzes the hydrolysis of a glucuronide moiety from a variety of substrates. This enzyme is present throughout biological systems, including bacteria up through humans. | '''β-glucuronidase''' is a ubiquitous enzyme that catalyzes the hydrolysis of a glucuronide moiety from a variety of substrates. This enzyme is present throughout biological systems, including bacteria up through humans. '''α-glucuronidase''' catalyzes the conversion of α-D-glucuronoside to alcohol and D-glucuronate. | ||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of glucuronisidase == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*'''Alpha-D-glucuronidase''' | |||
**[[1gqi]] – PcAGUS – Pseudomonas cellulosa <br /> | |||
**[[1k9d]], [[1mqp]] – GsAGUS – Geobacillus stearothermophilus <br /> | |||
**[[1mqr]] – GsAGUS (mutant) <br /> | |||
*Alpha-D-glucuronidase binary complex | |||
**[[1gqj]] – PcAGUS + xylobiose <br /> | |||
**[[1gqk]] – PcAGUS + glucuronic acid <br /> | |||
**[[1mqq]] – GsAGUS + glucuronic acid <br /> | |||
**[[1k9e]] – GsAGUS (mutant) + methyl-glucuronic acid <br /> | |||
**[[1k9f]] – GsAGUS (mutant) + aldotetraouronic acid <br /> | |||
**[[1h41]] – PcAGUS (mutant) + aldotriuronic acid <br /> | |||
*Alpha-D-glucuronidase ternary complex | |||
**[[1gql]] – AGUS + glucuronic acid + xylotriose – Cellvibrio japonicus<br /> | |||
**[[1l8n]] – GsAGUS (mutant) + methyl-glucuronic acid + xylotriose<br /> | |||
*'''Beta-glucuronidase''' | |||
**[[1bhg]], [[3hn3]] – hBGUS – human <br /> | |||
**[[3k46]] – EcBGUS – Escherichia coli <br /> | |||
**[[3k4a]] – EcBGUS (mutant) <br /> | |||
**[[3vny]] – AcBGUS – Acidobacterium capsulatum <br /> | |||
**[[4jkk]], [[4jkl]] – BGUS – Streptococcus agalactiae <br /> | |||
*Beta-glucuronidase binary complex | |||
**[[3vnz]] – AcBGUS + glucuronic acid <br /> | |||
**[[3vo0]] – AcBGUS + glucuronic acid derivative<br /> | |||
**[[3k4d]] – EcBGUS + glucaro-D-lactam <br /> | |||
**[[3lpf]], [[3lpg]], [[4jhz]] – EcBGUS + inhibitor <br /> | |||
**[[4jkm]] – BGUS + MBP – Clostridium perfringens <br /> | |||
}} | |||
== References == | == References == | ||
<ref>DOI:10.2210/pdb3hn3/pdb</ref> | <ref>DOI:10.2210/pdb3hn3/pdb</ref> | ||
<ref>DOI:10.2210/pdb3lpf/pdb</ref> | <ref>DOI:10.2210/pdb3lpf/pdb</ref> | ||
[[Category:Topic Page]] | |||
