Tachyplesin: Difference between revisions
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== A Cys Deleted Linear Analog == | == A Cys Deleted Linear Analog == | ||
<scene name='67/671725/Cdt/1'>CDT</scene> is a linear mutant lacking the cysteines and therfor also lacking the disulfide bonds (NH₂-Lys-Trp-Phe-Arg-Val-Tyr-Arg-Gly-Ile-Tyr-Arg-Arg-Arg-CONH₂). It contains a broad spectrum of bactericidal activity with a reduced hemolytic property that stems from selective interactions with the negatively charged lipids including LPS. | <scene name='67/671725/Cdt/1'>CDT</scene> is a linear mutant lacking the cysteines and therfor also lacking the disulfide bonds (NH₂-Lys-Trp-Phe-Arg-Val-Tyr-Arg-Gly-Ile-Tyr-Arg-Arg-Arg-CONH₂). It contains a broad spectrum of bactericidal activity with a reduced hemolytic property that stems from selective interactions with the negatively charged lipids including LPS. | ||
CDT demonstrated a marked inhibition of growth of Gram negative and Gram positive bacterial strains akin to TP-1. | |||
Its MIC values were found to be lower agains <i>E. Coli</i> and <i>Listeria monocytogenes</i> in comperison to the native TP-1 peptide. | |||
<ref name=Saravanan>PMID:22464970</ref> | <ref name=Saravanan>PMID:22464970</ref> | ||
