2fv5: Difference between revisions

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[[Image:2fv5.gif|left|200px]]<br /><applet load="2fv5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fv5.gif|left|200px]]
caption="2fv5, resolution 2.100&Aring;" />
 
'''Crystal structure of TACE in complex with IK682'''<br />
{{Structure
|PDB= 2fv5 |SIZE=350|CAPTION= <scene name='initialview01'>2fv5</scene>, resolution 2.100&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=541:(2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE'>541</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86]
|GENE= ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of TACE in complex with IK682'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FV5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=541:'>541</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV5 OCA].  
2FV5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV5 OCA].  


==Reference==
==Reference==
IK682, a tight binding inhibitor of TACE., Niu X, Umland S, Ingram R, Beyer BM, Liu YH, Sun J, Lundell D, Orth P, Arch Biochem Biophys. 2006 Jul 1;451(1):43-50. Epub 2006 May 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16762314 16762314]
IK682, a tight binding inhibitor of TACE., Niu X, Umland S, Ingram R, Beyer BM, Liu YH, Sun J, Lundell D, Orth P, Arch Biochem Biophys. 2006 Jul 1;451(1):43-50. Epub 2006 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16762314 16762314]
[[Category: ADAM 17 endopeptidase]]
[[Category: ADAM 17 endopeptidase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: tace adam17 zn-endopeptidase]]
[[Category: tace adam17 zn-endopeptidase]]


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