2fw4: Difference between revisions
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[[Image:2fw4.gif|left|200px]] | [[Image:2fw4.gif|left|200px]] | ||
'''Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.''' | {{Structure | ||
|PDB= 2fw4 |SIZE=350|CAPTION= <scene name='initialview01'>2fw4</scene>, resolution 2.00Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] | |||
|GENE= | |||
}} | |||
'''Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2FW4 is a [ | 2FW4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW4 OCA]. | ||
==Reference== | ==Reference== | ||
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:[http:// | Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16870440 16870440] | ||
[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: HIS]] | [[Category: HIS]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: | [[Category: activator]] | ||
[[Category: carbonic anhydrase i]] | [[Category: carbonic anhydrase i]] | ||
[[Category: crystal structure]] | [[Category: crystal structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:57:26 2008'' | ||
Revision as of 14:57, 20 March 2008
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| 2fw4, resolution 2.00Å | |||||||||||||
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| Ligands: | ZN and HIS | ||||||||||||
| Activity: | Carbonate dehydratase, with EC number 4.2.1.1 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.
Overview
The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.
About this Structure
2FW4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:16870440
Page seeded by OCA on Thu Mar 20 16:57:26 2008
