4nfk: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate==

~~The entry~~ 4nfk is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4nfk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFK OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFK FirstGlance].

~~Authors~~: ~~Park~~, J., ~~De schutter, J~~.W., ~~Tsantrizos, Y~~.S., ~~Berghuis, A~~.M.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4nfi|4nfi]], [[4nfj|4nfj]]</td></tr>

~~Description~~: ~~Crystal structure~~ of ~~human FPPS in complex~~ with ~~nickel~~, ~~JDS05120~~, and ~~sulfate~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfk RCSB], [http://www.ebi.ac.uk/pdbsum/4nfk PDBsum]</td></tr>

~~[[Category: Unreleased Structures]]~~

</table>

[[Category: ~~De Schutter~~, ~~J.W~~]]

== Function ==

[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

__TOC__

</StructureSection>

[[Category: Berghuis, A M]]

[[Category: Park, J]]

[[Category: ~~Berghuis~~, ~~A.M~~]]

[[Category: Tsantrizos, Y S]]

[[Category: ~~Tsantrizos~~, Y.S]]

[[Category: Schutter, J W.De]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate==
+<StructureSection load='4nfk' size='340' side='right' caption='[[4nfk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-The entry 4nfk is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nfk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFK FirstGlance]. <br>
-Authors: Park, J., De schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfi|4nfi]], [[4nfj|4nfj]]</td></tr>
-Description: Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfk RCSB], [http://www.ebi.ac.uk/pdbsum/4nfk PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: De Schutter, J.W]]
+== Function ==
+[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+__TOC__
+</StructureSection>
+[[Category: Berghuis, A M]]
 [[Category: Park, J]]
-[[Category: Berghuis, A.M]]
+[[Category: Tsantrizos, Y S]]
-[[Category: Tsantrizos, Y.S]]
+[[Category: Schutter, J W.De]]
+[[Category: Transferase-transferase inhibitor complex]]