Sandbox Reserved 975: Difference between revisions

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Ubiquitination is a post translationnal modification where an ubiquitin is attached to a protein. This modification has several consequences, it can lead to the degradation of the protein via the proteasome, it can change the protein localization or it can alter the interaction of the protein with other factors, this is why this modification plays an important role in the control of many cellular processes.

UBC9 in particular is important in the cell cycle progression because it allows the degradation of S phase and M phase cyclines.

UBC9, in particular, is important in the cell cycle progression because it allows the degradation of S phase and M phase cyclines.

Ubiquitination occurs in three steps : Activation performed by ubiquitin-activating enzymes E1, conjugation performed by ubiquitin-conjugating enzymes E2 and ligation performed by ubiquitin ligases E3.

Ubiquitination occurs in three steps : Activation performed by ubiquitin-activating enzymes E1, '''conjugation''' performed by ubiquitin-conjugating enzymes '''E2''' and ligation performed by ubiquitin ligases E3.

During the first step the Ct Carboxyl group of the ubiquitin is linked to the cystein sulfhydryl group of E1.

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UBC9 is a monomer of 158 amino acids.

It is comprised of a single domain with α helices and β-sheets, typical of the core domain of the UBCs.

It is comprised of a single domain with α helices and <scene name='60/604494/Beta-sheets/1'>TextToBeDisplayed</scene>, typical of the core domain of the UBCs.

The dimensions of the surface are 20 Å X 30 Å X 50 Å.

Sandbox Reserved 975: Difference between revisions

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@@ Line 8: / Line 8: @@
 Ubiquitination is a post translationnal modification where an ubiquitin is attached to a protein. This modification has several consequences, it can lead to the degradation of the protein via the proteasome, it can change the protein localization or it can alter the interaction of the protein with other factors, this is why this modification plays an important role in the control of many cellular processes.
-UBC9 in particular is important in the cell cycle progression because it allows the degradation of S phase and M phase cyclines.
+UBC9, in particular, is important in the cell cycle progression because it allows the degradation of S phase and M phase cyclines.
-Ubiquitination occurs in three steps : Activation performed by ubiquitin-activating enzymes E1, conjugation performed by ubiquitin-conjugating enzymes E2 and ligation performed by ubiquitin ligases E3.
+Ubiquitination occurs in three steps : Activation performed by ubiquitin-activating enzymes E1, '''conjugation''' performed by ubiquitin-conjugating enzymes '''E2''' and ligation performed by ubiquitin ligases E3.
 During the first step the Ct Carboxyl group of the ubiquitin is linked to the cystein sulfhydryl group of E1.
@@ Line 24: / Line 24: @@
 UBC9 is a monomer of 158 amino acids.
-It is comprised of a single domain with α helices and β-sheets, typical of the core domain of the UBCs.
+It is comprised of a single domain with α helices and <scene name='60/604494/Beta-sheets/1'>TextToBeDisplayed</scene>, typical of the core domain of the UBCs.
 The dimensions of the surface are 20 Å X 30 Å X 50 Å.