Sandbox Reserved 970: Difference between revisions
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The hydrolysis of one adenosine triphosphate (ATP) is essential for the functioning of the pump and the transport of one calcium ion. | The hydrolysis of one adenosine triphosphate (ATP) is essential for the functioning of the pump and the transport of one calcium ion. | ||
== Structural | == Structural Highlights == | ||
== Ligand and | == Ligand and Interaction == | ||
The architecture of calcium ATPase (determined by X-Ray crystallography) allow to understand mechanisms by which the energy of ATP is coupled to the calcium transport across a membrane. | The architecture of calcium ATPase (determined by X-Ray crystallography) allow to understand mechanisms by which the energy of ATP is coupled to the calcium transport across a membrane. | ||
Structurally, the pump contains 10 transmembrane domains (α helices), two large intracellular loops and amino/carboxy-terminal cytoplasmic tails. | Structurally, the pump contains 10 transmembrane domains (α helices), two large intracellular loops and amino/carboxy-terminal cytoplasmic tails. | ||
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The activity of the calcium pump is also regulated by by calmodulin, acidic phospholipids and phosphorylation by kinases A and C. Most of the activation mechanisms implicate the C-terminal region of the pump containing the high affinity calmodulin binding domain, which is involved in the autoinhibition of the pump. | The activity of the calcium pump is also regulated by by calmodulin, acidic phospholipids and phosphorylation by kinases A and C. Most of the activation mechanisms implicate the C-terminal region of the pump containing the high affinity calmodulin binding domain, which is involved in the autoinhibition of the pump. | ||
== Dysfunctions and | == Dysfunctions and Diseases == | ||
== References == | == References == | ||
